Small study indicates paroxetine may damage men's sperm, impair their fertility

Add anti-depressants to the list of substances that can damage men’s sperm and potentially impair their fertility.

According to a study published online in the journal Fertility & Sterility, antidepressants may "damage men's sperm and potentially impair their fertility." For the study, researchers from the Weill Cornell Medical College "followed 35 healthy men who took paroxetine for five weeks." The investigators then performed tests "to examine DNA fragmentation, which occurs when sperm DNA is missing pieces of the genetic code. The results showed that 50 percent of men had signs of abnormal DNA fragmentation while taking the drug, compared with less than 10 percent at the start of the trial." Following discontinuation of the drug, "the men's sperm returned to normal." The authors theorized that the "antidepressant caused men's sperm to slow down as it makes its way through the male reproductive tract," thereby "allowing it to age and become damaged."

“It’s fairly well known that SSRI anti-depressants negatively impact erectile function and ejaculation. This study goes on step further, demonstrating that they can cause a major increase in genetic damage to sperm,” said Dr. Peter Schlegel, the study’s senior author and professor of reproductive medicine at Weill Cornell Medical College in New York.

“Although this study doesn’t look directly at fertility, we can infer that as many as half of men taking SSRIs have a reduced ability to conceive. The amount, concentration and motility of sperm were not significantly changed by the medication.
Though men may not know it, sperm can be damaged by various substances, including smoking, alcohol, heat, anabolic steroids, drug abuse, sexually transmitted diseases and some environmental exposures.

Please remember, as with all our articles we provide information, not medical advice. For any treatment of your own medical condition you must visit your local doctor, with or without our article[s]. These articles are not to be taken as individual medical advice.

Deepen your understanding of "medical malpractice"... www.MedMalBook.com

For more health info and links visit the author's web site www.hookman.com